Hyperbaric Oxygen Therapy for Chronic Fatigue: A Comprehensive Guide
Chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME), is a complex and often debilitating condition characterised by persistent fatigue that doesn't improve with rest. Traditional treatments have limited efficacy, leading many patients to explore alternative therapies. One such therapy gaining attention is Hyperbaric Oxygen Therapy (HBOT).
How HBOT May Benefit Chronic Fatigue
1. Enhancing Cellular Energy Production
Mitochondria, the energy powerhouses of cells, require adequate oxygen to function optimally. HBOT can increase oxygen availability, potentially improving mitochondrial efficiency and reducing fatigue symptoms.
2. Reducing Inflammation
Chronic inflammation is a common feature in CFS. HBOT has been shown to modulate inflammatory pathways, helping to alleviate symptoms associated with inflammation.
3. Improving Circulation
By promoting the formation of new blood vessels, HBOT can enhance blood flow, ensuring that oxygen and nutrients are delivered more effectively to tissues, which may help in reducing fatigue.
4. Supporting Neurological Health
Some studies suggest that HBOT may improve cognitive function by enhancing oxygenation in the brain, potentially alleviating brain fog and cognitive difficulties common in chronic fatigue.
Scientific Evidence Supporting HBOT for Chronic Fatigue
While research is still emerging, several studies provide promising insights:
Pilot Study on HBOT for CFS: A 2013 pilot study published in Undersea & Hyperbaric Medicine assessed the effects of HBOT on CFS patients. The study found significant improvements in fatigue severity, sleep quality, and cognitive function following HBOT sessions.
Neurocognitive Improvements in Long COVID Patients: A 2022 study published in Frontiers in Neurology examined the impact of HBOT on neurocognitive function in patients with long COVID. The results indicated that HBOT led to significant improvements in cognitive performance, suggesting its potential utility in treating post-viral fatigue syndromes.
Long-Term Benefits of HBOT for Long COVID: A 2024 study published in Scientific Reports investigated the long-term effects of HBOT on patients with long COVID. The study found sustained improvements in fatigue, sleep quality, and cognitive function up to one year after completing HBOT sessions, highlighting its potential for long-term symptom management.
Case Report on HBOT for Chronic Inflammatory Response Syndrome: A 2025 case report published in Frontiers in Immunology described a patient with chronic inflammatory response syndrome who underwent HBOT. The patient experienced notable improvements in fatigue, cognition, and laboratory markers, suggesting that HBOT may be effective for conditions with overlapping symptoms to CFS.
Systematic Review on HBOT and Fatigue Reduction: A 2023 systematic review published in BMJ Open analyzed multiple studies on HBOT's effects on fatigue. The review concluded that HBOT is associated with significant reductions in fatigue, particularly in conditions like CFS and fibromyalgia, supporting its role in fatigue management.
Is HBOT Right for You?
HBOT may be considered for individuals with chronic fatigue who:
Have not responded adequately to conventional therapies
Are looking for complementary, non-pharmacological options
Are medically cleared to tolerate pressurised oxygen therapy
However, HBOT is not suitable for everyone. Contraindications may include untreated pneumothorax, certain lung diseases, or uncontrolled high blood pressure. A thorough consultation with your local GP is advised.
Conclusion
Hyperbaric Oxygen Therapy represents a promising approach for managing chronic fatigue by addressing underlying physiological challenges rather than simply masking symptoms. While research is still emerging, early evidence and patient experiences suggest benefits in energy production, inflammation reduction, circulation, and cognitive function.
